canadian online pharmacy rx female viagra for sale canadian online pharmacy rx canadian online pharmacy best generic cialis super active canadian online pharmacy rx

:




-
  .ARTICLES IN ENGLISH
. DIE ARTIKEL DEUTSCH


:




21.09.2005:
   21.09.2005

Rambler's Top100
  

PROSPECTS OF THE USE OF AMINO ACID PREPARATIONS IN THE TREATMENT OF AFTER-STROKE MOTOR DISORDERS.

V.A. Parfyonov, M.D., Professor
1997

INTRODUCTION

Motor disorders most frequently account for disability of patients with a cerebral insult history. Pathogenic therapy is most effective in early phases (first hours and days after insult); later on, therapeutic exercises combined with antispastic drugs (1) can play a leading part. The majority of similar preparations (baclophen, dantrolene, etc.) are short-acting, produce major side effects and are, therefore, not widely used in post-insult spastic pareses (2, 3).

In this connection, it appears promising to use amino acid compounds developed by A.P. Khokhlov being means of pathogenetic treatment of patients with post-insult motor disturbances.

MATERIAL AND STUDY METHODS

We supervised 40 patients who suffered cerebral insult with consequences in the form of spastic hemiparesis. The basic diseases in 36 patients were atherosclerosis, arterial hypertension and rheumatic heart disease (in 4 patients). The age of patients ranged from 35 to 65 years the mean age being 56 years. The stroke history varied between 2 months and 17 years the average length being 2 years and 3 months. Spastic hemiparesis of 0-1 point was found in 5 patients, of 2-3 points in 26 subjects and of 3-4 points in 9 subjects.

During 4-6 weeks all patients have been treated with amino acid preparations combined with therapeutic exercises (if indicated, antihypertensive and antiaggregative therapy was applied). 12 patients received Glucaprim at a dosage of either 1-3 capsules 4 times daily, 28 patients were given a combination of Glucaprim (1-2 capsules 4 times daily), Primavit (1-2 lozenges 4 times daily) and Neoprim (1-2 capsules daily).

STUDY RESULTS

Table

Results of the use of amino acid preparations in patients with post-insult spastic hemiparesis

Group of patients

Decreased spasticity

Decreased degree of hemiparesis

No.
%
No.
%
No.
%

Insult history

up to 1 year

16

100

14

88

10

63

Insult history

over 1 year

24

100

19

79

2

8

TOTAL
40
100
33
83
12
30

As can be seen from the findings in the Table, a positive effect in the form of diminished spasticity was recorded in 33 patients (83%); in 12 patients (30%) major decrease in hemiparesis (by 1-3 points the mean value being 1.4 point) was found. An antispastic effect was recorded in the majority of patients having both an insult history up to 1 year (88% of cases) and over 1 year (79% of cases). Decreased hemiparesis was registered more frequently in patients with a stroke history up to 1 year (63% of cases) than in those with a stroke history of more than 1 year (8% of cases).

A positive effect was marked in 5 patients who received amino acid preparations in the first 6 months following the stroke. In all patients a drop in spasticity and hemiparesis resulted in a considerable improvement of motor functions.

Although in many patients the use of amino acid preparations did not result in an appreciable decrease in the hemiparesis degree, yet it was accompanied by reduced spasticity and increased functional possibilities of the paretic limbs; patients reported not only a lesser constraint in the paretic limbs, but increased motor activity, improved gait and diminished fatiguability as well.

Amino acid treatment was not accompanied by major side effects. In some patients arterial tension variations, occasional headaches and dizziness were reported. These symptoms occurred in them also before treatment, however. On the contrary, most patients reported an improvement of their general condition and spirits, a normalization of sleep and stabilization of arterial tension.

The combination of Glucaprim with Primavit and Neoprim produced a positive effect more frequently (in 27 out of 28 patients) than administration of Glucaprim alone (in 6 out of 12 patients).

CONCLUSION

Treatment with amino acid preparations resulted in decreased spasticity in 83% of patients and diminished hemiparesis in 30% of patients with post-insult motor impairment. The combination of Glucaprim with Primavit and Neoprim proved the most efficient. The use of amino acid drugs is most promising within 1 year after insult occurrence; a positive effect was registered with a longer insult history, however.

REFERENCES (in Russian)

Gorbacheva, F.Ye., Skoromets, A.A., Yakhno, N.N. Vascular diseases of the brain and spinal cord. In: Nervous system diseases, vol. I, M., Meditsina, 1995, pp. 152-255.

Karlov, V.A. Therapy of nervous diseases. M., Meditsina, 1996.

Kogan, O.G., Naidin, V.L. Medical rehabilitation in neurology and neurosurgery . M., Meditsina, 1988.


 
   ©2006