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T.N. Bezprozvanova, Cand. Sc. (Med.), Asst. Prof., neurosurgeon


Traditional treatment of children with developmental defects of the central nervous system (CNS) envisages 2 aspects: 1) surgery aspect - restoration of normal liquorodynamics aimed at preventing compression, dislocation of brain hemispheres and trunk and eliminating compressions of the spinal cord and its roots in spinal patholohy; 2) therapeutic aspect when the treatment pattern includes vascular, vitamin preparations stimulants, etc. By the same token, it should be stressed that the clinical experience stretching over many years leads to the conclusion that both the 1st and 2nd method do not produce any significant improvement of motor impairment in children.

In earlier studies (A.P. Khokhlov et al., 1994, 1995) new conceptual approaches to the treatment of patients with demyelinating diseases, polyneuropathies and brain circulation disorders were demonstrated.

The objective of the present study was to determine possibilities of using amino acids in the treatment of children with developmental defects of the brain and spinal cord.


The group of children with developmental defects of the central nervous system (CNS) included 26 patients: 5 of them had arachnoid cysts of the brain; 2 patients had arachnoid cysts of the spinal cord; meningoceles of the meningomyeloradiculocele-type were found in 4 patients; agenesia of the cerebellum worm was identified in 3 cases; agenesia of corpus callosum was found in 1 female patient; hydrocephaly was detected in 6 and microcephaly in 5 subjects.

All patients underwent clinical examination; the diagnosis was verified with the aid of CT or MRT.


Treatment with amino acid compounds was applied in 4 patients with arachnoid cysts of the sylvian split in the clinical picture of which spastic hemiparesis was prevalent. Already after the second or third week of amino acid drug treatment (Glucaprim, Aminovil, Aminovit, Primavit) a decrease in the muscular tone and increase in the amount of movements in paretic limbs were recorded. As an example we cite the case history of the patient G-v A., 3 years. The patient had inborn right-sided spastic hemiparesis that was found to be a consequence of dyshemic disturbances at birth. The child repeatedly received courses of rehabilitation therapy in inpatient departments and clinics that included vascular, vitamin preparations, nootropic agents and physiotherapeutic treatment - all to no avail. The CT revealed an arachnoid cyst of the left temporal region. The operation performed, cystoperitoneostomy, did not improve motor functions.

In the present examination the child retained right-sided hemiparesis of spastic nature that was predominant in the arm (Wernicke-Mann posture). The child could not flex his arm in the elbow joint, open the palm or move fingers. Treatment with amino compounds yielded the following results: spasticity in the right arm decreased by the end of the second week; after the fourth week the patient could extend fingers; the child moved more easily; weakness in the right leg decreased considerably.

Example 2. The patient N., 7, with the diagnosis arachnoid cyst of the lamina quadrigemina plate. The basic symptoms were: divergent squint, wobbly gait, incoordination, mental and speech retardation. The first course of treatment (Glucaprim, Aminovit, Vitamixt) produced an improvement of oculomotor nerves, coordination, statics, gait and intelligence.

In 2 patients arachnoid cysts were located at the level of C5-C7 vertebrae and at the sacral level. In the first case (patient P-n D., 6 years) the basic symptom was spastic tetraparesis. The previously performed operative intervention revealed spinal cord splitting in the arachnoid cyst region at the level of the C5-C7 vertebrae. Following excision of the cyst walls, the patient did not have an improvement of motor functions. The child was practically immobile. Treatment (1st course) with Glucaprim, Neoprim, Neurovit and Aminovil contributed to a gain in the strength of the back muscles and proximal regions of upper extremities; the child began to sit easily without helping with the hands and move around in the room (by creeping).

The girl patient Vl-va Yu., 6, with an arachnoid cyst of the sacral region showed, following 1 course of treatment (Glucaprim, Aminovil, Neoprim) a significant (by 7%) regression of the lower spastic paraparesis, a decrease in varus deformity of the feet, an improvement of statics and gait.

The clinical picture of children with myelomeningoradiculocele was dominated by symptoms of flaccid lower paraparesis. Following a course of treatment with amino acids (Glucaprim, Aminovil, Neoprim, Neurovit), an improvement of movements and of the strength in the muscles of the back, hips and, to a lesser extent, of the feet was recorded. The children became more energetic, were willing to move more; their spirits rose.

Statokinetic disturbances, reduction in vision acuity and oculomotor disorders were found in 3 children with cerebellum worm agenesia. Once a course of treatment completed (Glucaprim, Neoprim, Neurovit), they developed stability in walking; acuity of vision improved, squint diminished. 1 child suffering from corpus callosum agenesia with concomitant ventriculomegaly had mental and speech retardation. Following a treatment period (Glucaprim, Aminovil, Vitamixt, Aminocomposit, Cerebron), an improvement of auditory attention and perception, an increase in working capacity, an enlargement of passive vocabulary and a notable increase in visual perception were recorded.

Six children with hydrocephaly were supervised. Four of them had a remote shunting operation on the liquor system; 1 had subcompensated form; 1 patient showed a severe, neglected form of aresorptive hydrocephaly in combination with severe ischemic cerebral impairment. Two syndromes prevailed in the clinical picture: spastic tetraparesis and vision disturbances. Treatment with amino acids (2 courses) produced intensification of movements in the arms and legs; a gain in strength was registered. The children could sit up, turn around in bed, stand and walk when supported. Sight became more acute. On the background of prolonged intake of amino acid compounds (4 courses), an increase in the intellectual potential, improved small movements of the fingers, improved statics and gait were recorded in all children with microcephaly. The circumference of the head increased by 2-4 cm.


Thus, the analysis has demonstrated large potentialities of using amino acids in managing most severe types of developmental anomalies of the central nervous system where, as it seemed, any progress in the motor and intellectual sphere was precluded.

REFERENCE (in Russian)

Khokhlov, A.P., Savchenko, Yu.S. Myelopathies and demyelinating diseases. Moscow, Meditsina, 1990.