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Rambler's Top100


A.A. Savin, M.D., Ass. Prof., neuropathologist


It is common knowledge that, according to electroencephalography (EEG) data, the child's brain becomes the adult's brain by 14-16 years. This may explain why the efficacy of conventional rehabilitation measures taken to treat infantile cerebral palsy (ICP) clearly diminishes after this age since compensatory possibilities get exhausted. Therefore, a search for methods that would give impetus to further positive dynamics of the neurologic status in ICP patients is topical. The ICP treatment method that has been suggested by Prof. A.P. Khokhlov in 1990 the basis of which is formed by the use of original combinations of amino acid preparations provided some optimism as to the possibility of therapy in this category of patients.


55 ICP patients were examined and treated, their mean age being 24.1 years. There were 25 male and 28 female subjects. In all subjects their intelligence was intact; in history taking the majority of them stressed that for many years their condition had been stable and traditional treatment methods had not been producing any positive effect.

In this connection, when assessing treatment results, we attached, alongside objective findings, special importance to patients' subjective sensations they experienced during treatment.

Among the group of patients observed, in 11 patients spastic diplegia was recorded; hemipareses were found in 8, tetrapareses in 9; the hyperkinetic form of disease was identified in 10 patients; in 14 patients a mixed form was noted when hyperkineses combined with pareses of limbs. Epileptic attacks were observed in 6 subjects; in 1 female patient myclonias in muscles of the legs occurred over many years. The course of treatment lasted 4-6 weeks.

To manage spastic forms of the disorder, Glucaprim, Aminovil, Primavit, including their combinations, were most often prescribed. To influence hyperkineses, depending on their type (slow, rapid), Trevit, Detrem, Aminocomposit, Vitamixt, Prima-F at individually selected dosages and in combinations were given. Glucaprim and Neoprim were administered to act on cerebellar disorders.


The thing that was most hard to understand was that a subjective effect was recorded in 52 (!) out of 53 patients as well as the fact that patients noted an improvement of their condition already within the first week of treatment. Attention should be once again drawn to the fact that prior to the course of treatment patients had felt no changes in their condition over many years!

Among objective symptoms, a manifest decrease in the muscular tone was primarily recorded which concurrently combined with an increase in the force and in the volume of movements as well as with the appearance of new movements. Such dynamics was registered in all patients with spastic forms of the disease.

Diminished muscular tonicity and reduced dystonic manifestations in patients with slow hyperkineses, along with an improvement of the subjective condition, enabled these patients to execute more purposeful movements. At the same time, patients reported a clear-cut reduction of dysarthria manifestations; their mimics became more lively. The concomitant prescription of Aminovil and Aminocomposit turned out to be an effective combination that affected tic hyperkinesias in the facial area. The degree of manifestation of tics in 5 patients decreased in all. Furthermore, all patients pointed out they managed to more easily suppress tics by volitional effort.

The efficacy of amino acid preparations was less pronounced with regard to rapid hyperkineses against the background of low tonicity; hyperkineses decreased after treatment mainly in rest.

A marked clinical effect was recorded in respect to the convulsive syndrome. In 4 out of 6 patients who suffered from epileptic fits a reduced occurrence of attacks was recorded. An astonishing effect was obtained in an 19-year old female patient who for 12 years had been suffering from daily multiple myoclonic fits in the legs that drastically impaired her walking. Aminovil treatment resulted in total elimination of myoclonias that did non yield to any preparations before.

27 patients with pareses in the legs but who could walk noted decreased fatiguability in the legs; in walking they could make a wider step, cover a larger distance; their walking rate increased.

No substantial side effects of amino acid drugs that would call for their withdrawal were recorded.

23 patients underwent repeated courses of treatment. All of them stressed that between the courses, the effect achieved after the previous course was mainly retained which they had never noticed earlier when they were treated conventionally.


The analysis of the direct results of treating patients has demonstrated that the method offered was a qualitatively new advance in the potentialities of infantile cerebral palsy treatment. Both subjective and objective effects, the rapidity of their recording in adult patients who had been in a stable condition over many years can be explained only by new compensatory mechanisms that were not involved before but began to act in the brain under the influence of amino acid combinations. An analysis of even preliminary findings permits to highly assess the method presented.