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S.P. Novikov, psychoneurologist


An analysis of the present-day world literature allows the statement that the use of traditional methods of treating alcoholism and addictions does not produce the desired effect. Although a large variety of specific medications is used in modern narcology - psychotropic, desintoxicating and plasma substituting drugs, vitamins, hormones, microelements, etc., the therapeutic effect turns out to be unstable.

In recent years, pathogenetic treatment of alcoholism and addictions has been predominant in narcology. Drugs that are administered eliminate the impaired neuromediator processes in limbic brain structures. In this respect, a great deal of studies is concerned with correction of dophamine and neuropeptide exchange.

Thus, in narcologic practice small doses of dophamine receptor stimulators (apomorphine, bromocriptine), peptide drugs (pancreozymine, takus, angiotensin), opiate receptor blockers (naloxone, naltrexone), antidepressants that primarily act through the serotonin system, neuroleptics, tranquilizers, anticonvulsants, etc. are used. The listed drugs have not found wide acceptance in treating alcoholism and addictions since they have numerous contraindications, side effects and complications while the therapeutic effect is often unstable and unpronounced.

This is why the objective of this study was to use natural metabolite-amino acids as basic therapeutic agents designed to correct disrupted metabolism links in alcoholics and addicts.


Since 1995, 76 alcoholic patients and 22 addicts have been observed at the Primavera Medica Center. In the group of alcoholics in 64 patients the moderate (abstinent) illness phase was verified. The patients were aged 18-50 years, they were socially intact, able-bodied persons living in families, and 12 patients with pronounced encephalopathic alterations whose disease was in the final development phase. The patients were 45-60 years old. Most of the patients have been treated for many years in narcologic and outpatient clinics. Remission of the disease in patients corresponded to periods of absolute abstinence from alcohol ordered by the physician. In most cases, relapses into the disease were due to social problems or a state of mental stress in patients which forced many patients to return to alcohol abuse and, thus, to protract the disease. Practically, all patients showed a different degree of psychic disorders and signs of emerging dementia.

In the group of addicts there were 16 patients with dependence on opium and its derivatives and 6 patients who took stimulants (Pervitin). Their age varied from 16 to 32 years. All were socially dysadapted persons with psychoneurotic manifestations resistant to traditional methods of addiction treatment, with absent remissions, but all were willing to get cured. The patients had all the structural components of a narcomanic syndrome.

The treatment of alcoholism and addictions was conducted both in disease exacerbation and in remission periods (pseudoabstinent conditions). The treatment lasted 21-28 days.

Only amino acid compounds were administered as therapeutic drugs.


The analysis of clinical material enables a conclusion on a positive effect of amino acid compounds on the course of the pathologic process. Thus, in practically all alcoholic patients abstinence (from a mild to a middle-severe degree), one of the striking and painful conditions, was arrested in 3-7 days after commencement of treatment with amino acids.

At the same time, the amount of alcohol consumed was reduced up to complete rejection.

Mild abstinent manifestations are easily eliminated with Aminovil. In a middle degree status, a combination of Aminovil-Aminocomposit is more effective. Alcoholic abstinences of a middle-severe degree are successfully stopped by Quadro-D, in particular, in combination with Aminocomposit.

Observation. Patient Sch., 39, with the diagnosis: 2nd-3rd stage of alcoholism in dipsomanic form. Progredient type of the disease course. Toxic encephalopathy and polyneuropathy. Alcoholic hepatosis. Alcoholic cardiopathy. The patient was repeatedly admitted to narcologic clinics in severe abstinent condition, with no effect, though. In our case, the Quadro-D administration on an outpatient basis abolished abstinence within 7 days. After follow-up treatment, the patient's condition stabilized; a regression of somatoneurologic pathology occurred. It should be pointed out that during amino compound treatment the pathologic drive for alcohol was eliminated.

The somatoneurological pathology describing various lesions of the cardiovascular system, the liver, the gastrointestinal tract, the pancreas, the hematopoietic system, the central and peripheral nervous system (encephalopathies, polyneuropathies) showed a reversal.

Treatment of addicts is of specific nature. Certainly, patients in acute intoxication state must be urgently admitted to toxicological centers and those with psychopathologic disturbances to mental hospitals.

At our Center addiction treatment is conducted on an outpatient basis. In the group of opiomania subjects the bulk of the patients had the 2nd degree of narcotic dependence. The treatment starts with the Quadro-D compound of feeble effectiveness; in middlee-severe conditions the combination of Quadro-D- Aminocomposit is prescribed.A diseased condition, such as physical abstinence with vegetative and somatoneurlogic symptomatology, subsided by the 3rd-5th day and disappeared by the 7th-15th day. Already in the first week of treatment the form of drug intake changed from systematic to episodic; by the end of the 3rd week total rejection of drug intake occurred. Simultaneously, a progressive reduction in the dose of the psychoactive substance by 3-6 times compared with the initial dose was recorded. Patients reported a change in intensity and quality of euphoria from arousing to sedative effect and a feeling of complete "emptiness". Drive intensity falls from compulsive to obsessive already in the first week of the treatment.

Observation. The patient S., 38, with the diagnosis: opium addiction of the 2nd-3rd stage. Malignant progression. Toxic hepatitis. Toxic encephalopathy. Continuous drug taking during 1 year. Was twice admitted to an inpatient unit, repeated hemosorption and hemodialysis. No effect was recorded. Personal attempts to discontinue narcotics failed. Against the background of a Quadro-D- Aminocomposit combination, the drug dosage decreased 6 times by the end of the 2nd week; the algesic syndrome was arrested by the 7th day; abstinence was recorded by the end of the 2nd week. Sleep and appetite returned back to normal, weight and physical strength increased. The patient became adequate, optimistic and resumed work. The subject consumed the drug once in 3 days in the evening in the company of his friends; he didn't experience earlier sensations or any pathologic compulsion. By the end of the 4th week categoric rejection of drug use occurred, followed by an improvement of the somatoneurological condition; jaundice vanished; intestinal dyspepsia manifestations wore off; biochemical blood indices stabilized.

In treating patients who abused stimulants (Pervitin), no substantial differences were observed. The group comprised patients who had psychoorganic alterations in the premorbid condition. Periods of the suppression of intoxications and abstinence phenomena varied between 7 and 15 days. The preparation of choice was Quadro-D. The patients were mainly concerned about their intellectual-mnestic impairment. By the end of the treatment, the patients got socially adapted, took up college studies or began to work.

The duration of a favorable condition varies from 6 to 12 months and longer; in the event of a relapse into the use of psychoactive substances remission time diminishes, yet the abstinence condition occurring in this case is not very pronounced. In similar cases a repeated treatment period is recommended.

In three drug addicts the recurrence of the disease under supervision was caused by emotional and stress loads. Their condition of well-being lasted from 3 to 5 months. Already in the first week of amino compound and Quadro-D treatment abstinence and intoxication symptoms disappeared.

No positive effect was recorded in 4 alcoholic patients who suffered from concomitant endogeneous mental disorders.


The method of alcoholism and addiction pathogenetic treatment with amino acid compounds developed in the Primavera Medica Center is both effective and easy to apply. In our practice amino acid compounds are the principal basic therapy medications. The absence of contraindications and complications enables the patients to take amino acid compounds independently, under occasional supervision of a specialist.

REFERENCES (in Russian)

Anokhina, I.P. Modern concept of treatment of alcoholic patients and addicts. All-Russian Center of Narcology of the I.M. Sechenov Academy of Medical Sciences. Journal Problems of Narcology, M., 1991.

Rayevsky, K.S., Georgiev, B. (Bulgaria). Mediator amino acids. M., Meditsina, 1986.

Bilibin, D.P., Dvornikov, V.Ye. Pathophysiology of alcoholism and addictions . M., Peoples' Friendship University, 1991.

Pyatnitskaya, I.N. Narcomanias, M., 1994.